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GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a <i>Trp53 null</i> background

29 Dec 2008

Abstract excerpt

Glioblastomas are the most common and malignant astrocytic brain tumors in human adults. The tumor suppressor gene TP53 is commonly mutated and/or lost in astrocytic brain tumors and the TP53 alterations are often found in combination with excessive growth factor signaling via PDGF/PDGFRalpha. Here, we have generated transgenic mice over-expressing human PDGFB in brain, under control of the human GFAP promoter....

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PMID: 19115382
DOI: 10.1002/glia.20837

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