Article
A Mouse Model for Glioma: Biology, Pathology, and Therapeutic Opportunities
1 Jan 2000
Abstract excerpt
The epidermal growth factor receptor (EGFR) gene is amplified or mutated in 30-50% of human glioblastoma multiforme. These mutations are usually associated with deletions of the INK4a-ARF locus, which encodes 2 gene products (p16INK4a and p19ARF) involved in cell cycle arrest and apoptosis. We have investigated the role of EGFR mutation in gliomagenesis using avian retroviral vectors to transfer a mutant EGFR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.