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Glioma-Derived Platelet-Derived Growth Factor-BB Recruits Oligodendrocyte Progenitor Cells via Platelet-Derived Growth Factor Receptor-α and Remodels Cancer Stroma.

The American journal of pathology - 1 May 2016

Zheng Yang, Yamamoto Seiji, Ishii Yoko, Sang Yang, Hamashima Takeru, Van De Nguyen, Nishizono Hirofumi, Inoue Ran, Mori Hisashi, Sasahara Masakiyo

Abstract excerpt

Glioma is an aggressive and incurable disease, and is frequently accompanied by augmented platelet-derived growth factor (PDGF) signaling. Overexpression of PDGF-B ligand characterizes a specific subclass of glioblastoma multiforme, but the significance of the ligand remains to be elucidated. For this end, we implanted a glioma-cell line transfected with PDGF-BB-overexpressing vector (GL261-PDGF-BB) or control...

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PMID: 26945107
DOI: 10.1016/j.ajpath.2015.12.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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