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Article

Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Jin Hong, Gebska Milena A, Blokhin Ilya O, Wilson Katina M, Ketsawatsomkron Pimonrat, Chauhan Anil K, Keen Henry L, Sigmund Curt D, Lentz Steven R

Abstract excerpt

OBJECTIVE: We tested the hypothesis that endothelial peroxisome proliferator-activated receptor-γ protects against vascular thrombosis using a transgenic mouse model expressing a peroxisome proliferator-activated receptor-γ mutant (E-V290M) selectively in endothelium. APPROACH AND RESULTS: The time to occlusive thrombosis of the carotid artery was significantly shortened in E-V290M mice compared with...

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Identifiers

PMID: 25675995
DOI: 10.1161/ATVBAHA.115.305378
PMCID: PMC4376629

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