Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium.

doi:10.1161/ATVBAHA.116.307843

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Article

Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Kirsch Julian, Schneider Holger, Pagel Judith-Irina, Rehberg Markus, Singer Miriam, Hellfritsch Juliane, Chillo Omary, Schubert Kai Michael, Qiu Jiehua, Pogoda Kristin, Kameritsch Petra, Uhl Bernd, Pircher Joachim, Deindl Elisabeth, Müller Susanna, Kirchner Thomas, Pohl Ulrich, Conrad Marcus, Beck Heike

Abstract excerpt

OBJECTIVE: Although the investigation on the importance of mitochondria-derived reactive oxygen species (ROS) in endothelial function has been gaining momentum, little is known on the precise role of the individual components involved in the maintenance of a delicate ROS balance. Here we studied the impact of an ongoing dysregulated redox homeostasis by examining the effects of endothelial cell-specific deletion...

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PMID: 27386940
DOI: 10.1161/ATVBAHA.116.307843

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