KLRE1 shapes antifungal immunity by tuning dendritic cell and T cell activation through distinct heterodimeric partners

Abstract excerpt

Dendritic cells (DCs) instruct adaptive immunity by integrating inflammatory cues to regulate co-signalling molecules and T cell activation. We recently discovered that the pattern recognition receptor Dectin-1 (Clec7a) controls expression of a network of killer lectin-like receptors (KLRs), including KLRI1 and KLRI2, which regulate adaptive immune responses. Here, we identify KLRE1 as a key regulator of DC phenot...

Topics

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• Antifungal resistance and susceptibility
• Aspergillus fumigatus
• beta-Glucans
• Candida albicans
• Fungal Infections and Studies
• Lectins, C-Type
• Plant-Microbe Interactions and Immunity
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

2629276d-e1f2-54f7-9b3b-113dc5e0229f

DOI

10.64898/2025.12.03.690303