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Article

Persistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in Malawi.

The Journal of infectious diseases - 1 Sept 2015

Artimovich Elena, Schneider Kristan, Taylor Terrie E, Kublin James G, Dzinjalamala Fraction K, Escalante Ananias A, Plowe Christopher V, Laufer Miriam K, Takala-Harrison Shannon

Abstract excerpt

BACKGROUND: In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with an artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. Here we estimate the effect of reduced SP pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci....

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Source

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Identifiers

PMID: 25672905
DOI: 10.1093/infdis/jiv078
PMCID: PMC4539899

Genes

DHPS
DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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