Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr/pfdhps alleles.

doi:10.1093/jac/dky258

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Article

Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr/pfdhps alleles.

The Journal of antimicrobial chemotherapy - 1 Oct 2018

Nkoli Mandoko Papy, Rouvier Florent, Matendo Kakina Lebon, Moke Mbongi Destin, Latour Christine, Losimba Likwela Joris, Ngoyi Mumba Dieudonné, Bi Shamamba Stomy Karhemere, Tamfum Muyembe Jean-Jacques, Muepu Tshilolo Léon, Parzy Daniel, Sinou Véronique

Abstract excerpt

Background: In 2005, the Democratic Republic of the Congo (DRC) switched to artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine/pyrimethamine resistance and adopted intermittent preventive treatment using sulfadoxine/pyrimethamine in pregnancy. Objectives: To determine the prevalence of molecular markers of sulfadoxine/pyrimethamine resistance in southwestern DRC 10 years...

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PMID: 30053021
DOI: 10.1093/jac/dky258

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