Article
High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi.
Acta tropica - 1 Mar 2003
Bwijo B, Kaneko A, Takechi M, Zungu I L, Moriyama Y, Lum J K, Tsukahara T, Mita T, Takahashi N, Bergqvist Y, Björkman A, Kobayakawa T
Abstract excerpt
Malawi changed its national policy for malaria treatment in 1993, becoming the first country in Africa to replace chloroquine by sulfadoxine and pyrimethamine combination (SP) as the first-line drug for uncomplicated malaria. Seven years after this change, we investigated the prevalence of dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) mutations, known to be associated with decreased...
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