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Article

Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi.

Malaria journal - 29 Nov 2016

Ravenhall Matt, Benavente Ernest Diez, Mipando Mwapatsa, Jensen Anja T R, Sutherland Colin J, Roper Cally, Sepúlveda Nuno, Kwiatkowski Dominic P, Montgomery Jacqui, Phiri Kamija S, Terlouw Anja, Craig Alister, Campino Susana, Ocholla Harold, Clark Taane G

Abstract excerpt

BACKGROUND: Malawi experienced prolonged use of sulfadoxine/pyrimethamine (SP) as the front-line anti-malarial drug, with early replacement of chloroquine and delayed introduction of artemisinin-based combination therapy. Extended use of SP, and its continued application in pregnancy is impacting the genomic variation of the Plasmodium falciparum population. METHODS: Whole genome sequence data of P. falciparum...

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Identifiers

PMID: 27899115
DOI: 10.1186/s12936-016-1634-6
PMCID: PMC5129638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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