Article
Interactions Between Antenatal Sulfadoxine-Pyrimethamine, Drug-Resistant Plasmodium falciparum Parasites, and Delivery Outcomes in Malawi.
The Journal of infectious diseases - 23 Jul 2020
Taylor Steve M, Levitt Brandt, Freedman Betsy, Madanitsa Mwayiwawo, Thwai Kyaw-Lay, Kalilani-Phiri Linda, Khairallah Carole, Mwapasa Victor, Ter Kuile Feiko O, Meshnick Steven R
Abstract excerpt
BACKGROUND: Sulfadoxine-pyrimethamine (SP) is used as intermittent preventive therapy in pregnancy (IPTp) for malaria in sub-Saharan Africa. The resistance marker dhps A581G has been associated with reduced IPTp-SP efficacy and enhanced morbidity in SP recipients. METHODS: We measured SP-resistance allele frequencies in Malawian women participating in a trial comparing IPTp with SP against intermittent screening...
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