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Molecular monitoring of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in western Kenya, 14 years after its withdrawal

2019-04-16

Abstract excerpt

<h4>Background: </h4> The application of chloroquine (CQ) as an antimalarial drug for over half a century and subsequent development of CQ-resistant Plasmodium strains has led to its withdrawal and replacement with sulphadoxine-pyrimethamine (SP). In 2004, SP was replaced with artemisinin-based combination therapy (ACT) as a first-line against uncomplicated malaria in Kenya. The sudden surge in ACT resistant again...

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Literature Corpus work
48b9f1b8-57fc-5da5-b928-008a20346cb4
DOI
10.21203/rs.2.9218/v1
Open publication

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