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Article

Impact of Trimethoprim-Sulfamethoxazole and Chloroquine Prophylaxis on Drug-Resistant Plasmodium falciparum Mutations in Adults with HIV in Malawi.

The American journal of tropical medicine and hygiene - 3 Dec 2025

Fairhurst Kate J, Mungwira Randy G, Divala Titus H, Nyirenda Osward M, Masonga Rhoda, Joshi Sudhaunshu, Fern Nicole, van Oosterhout Joep J, Laufer Miriam K, Laurens Matthew B

Abstract excerpt

Drug resistance is a major obstacle for malaria control and elimination. Prophylactic antimalarial drug use may contribute to antimalarial drug resistance. We evaluated samples collected from a randomized, controlled clinical trial comparing chloroquine (CQ) with trimethoprim-sulfamethoxazole (TS) prophylaxis among adults with HIV on successful antiretroviral therapy in Malawi. We hypothesized that compared with...

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Identifiers

PMID: 41160908
DOI: 10.4269/ajtmh.25-0136
PMCID: PMC12643122

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