Article
Impact of Trimethoprim-Sulfamethoxazole and Chloroquine Prophylaxis on Drug-Resistant Plasmodium falciparum Mutations in Adults with HIV in Malawi.
The American journal of tropical medicine and hygiene - 3 Dec 2025
Fairhurst Kate J, Mungwira Randy G, Divala Titus H, Nyirenda Osward M, Masonga Rhoda, Joshi Sudhaunshu, Fern Nicole, van Oosterhout Joep J, Laufer Miriam K, Laurens Matthew B
Abstract excerpt
Drug resistance is a major obstacle for malaria control and elimination. Prophylactic antimalarial drug use may contribute to antimalarial drug resistance. We evaluated samples collected from a randomized, controlled clinical trial comparing chloroquine (CQ) with trimethoprim-sulfamethoxazole (TS) prophylaxis among adults with HIV on successful antiretroviral therapy in Malawi. We hypothesized that compared with...
Topics
- Humans
- Trimethoprim, Sulfamethoxazole Drug Combination
- Malawi
- Malaria, Falciparum
- Antimalarials
- Chloroquine
- Adult
- Drug Resistance
- Plasmodium falciparum
- Mutation
- HIV Infections
- Male