Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.

doi:10.1016/j.actatropica.2016.09.008

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Article

Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.

Acta tropica - 1 Dec 2016

Kateera Fredrick, Nsobya Sam L, Tukwasibwe Steven, Hakizimana Emmanuel, Mutesa Leon, Mens Petra F, Grobusch Martin P, van Vugt Michèle, Kumar Nirbhay

Abstract excerpt

Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria. Following yea...

Topics

Adolescent
Amodiaquine
Antimalarials
Child
Child, Preschool
Chloroquine
Drug Combinations
Drug Resistance
Female
Genotype
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Infant, Newborn

Kenya

Malaria

Malaria, Falciparum

Malawi

Source

Open in PubMed Open full text

Identifiers

PMID: 27647575
DOI: 10.1016/j.actatropica.2016.09.008
PMCID: PMC10600949

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27647575-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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