Article
The A581G Mutation in the Gene Encoding Plasmodium falciparum Dihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women.
The Journal of infectious diseases - 15 Jun 2015
Gutman Julie, Kalilani Linda, Taylor Steve, Zhou Zhiyong, Wiegand Ryan E, Thwai Kyaw L, Mwandama Dyson, Khairallah Carole, Madanitsa Mwayi, Chaluluka Ebbie, Dzinjalamala Fraction, Ali Doreen, Mathanga Don P, Skarbinski Jacek, Shi Ya Ping, Meshnick Steve, ter Kuile Feiko O
Abstract excerpt
BACKGROUND: The A581 G: mutation in the gene encoding Plasmodium falciparum dihydropteroate synthase (dhps), in combination with the quintuple mutant involving mutations in both dhps and the gene encoding dihydrofolate reductase (dhfr), the so-called sextuple mutant, has been associated with incr...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.