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Article

Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi.

PloS one - 13 Feb 2008

Bell David J, Nyirongo Suzgo K, Mukaka Mavuto, Zijlstra Ed E, Plowe Christopher V, Molyneux Malcolm E, Ward Steve A, Winstanley Peter A

Abstract excerpt

BACKGROUND: In Malawi, there has been a return of Plasmodium falciparum sensitivity to chloroquine (CQ) since sulfadoxine-pyrimethamine (SP) replaced CQ as first line treatment for uncomplicated malaria. When used for prophylaxis, Amodiaquine (AQ) was associated with agranulocytosis but is considered safe for treatment and is increasingly being used in Africa. Here we compare the efficacy, safety and selection of...

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Identifiers

PMID: 18270569
DOI: 10.1371/journal.pone.0001578
PMCID: PMC2229666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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