Article
The effect of local variation in malaria transmission on the prevalence of sulfadoxine-pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi.
Malaria journal - 5 Oct 2015
Artimovich Elena, Kapito-Tembo Atupele, Pensulo Paul, Nyirenda Osward, Brown Sarah, Joshi Sudhaunshu, Taylor Terrie E, Mathanga Don, Escalante Ananias A, Laufer Miriam K, Takala-Harrison Shannon
Abstract excerpt
BACKGROUND: Persistence of sulfadoxine-pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this...
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