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Article

Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein.

Brain research - 16 Apr 2015

Liu Feng-Tao, Chen Yan, Yang Yu-Jie, Yang Ling, Yu Mei, Zhao Jian, Wu Jian-Jun, Huang Fang, Liu Wen, Ding Zheng-Tong, Wang Jian

Abstract excerpt

Mutations and excessive accumulation of α-synuclein (α-syn) can lead to the degeneration of dopaminergic neurons, indicating a pivotal role of α-syn in the pathogenesis of Parkinson's disease (PD). Although how α-syn contributes to PD is still elusive, mitochondrial impairments have been reported to be implicated in. Mortalin, a molecular chaperone mainly located in mitochondria, has been linked to the...

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PMID: 25665531
DOI: 10.1016/j.brainres.2015.01.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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