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Article

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.

Human molecular genetics - 15 Nov 2010

Burbulla Lena F, Schelling Carina, Kato Hiroki, Rapaport Doron, Woitalla Dirk, Schiesling Carola, Schulte Claudia, Sharma Manu, Illig Thomas, Bauer Peter, Jung Stephan, Nordheim Alfred, Schöls Ludger, Riess Olaf, Krüger Rejko

Abstract excerpt

The mitochondrial chaperone mortalin has been linked to neurodegeneration in Parkinson's disease (PD) based on reduced protein levels in affected brain regions of PD patients and its interaction with the PD-associated protein DJ-1. Recently, two amino acid exchanges in the ATPase domain (R126W) a...

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Identifiers

PMID: 20817635
DOI: 10.1093/hmg/ddq370
PMCID: PMC3298849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20817635-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.PMID 20817635Read ↗

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