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Article

Association of p53 with Neurodegeneration in Parkinson’s Disease

1 Jan 2022

Abstract excerpt

p53 is a vital transcriptional protein implicated in regulating diverse cellular processes, including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis, autophagy, senescence, and apoptosis. Recent studies have revealed that p53 levels and activity are substantially increased in affected neurons in cellular and animal models of Parkinson's disease (PD) as well as in the brains of PD...

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PMID: 35601652
DOI: 10.1155/2022/6600944

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