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Article

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition

8 May 2021

Abstract excerpt

Abstract TP53INP1 is a stress-induced protein, which acts as a dual positive regulator of transcription and of autophagy and whose deficiency has been linked with cancer and metabolic syndrome. Here, we addressed the unexplored role of TP53INP1 and of itsDrosophilahomolog dDOR in the maintenance of neuronal homeostasis under chronic stress, focusing on dopamine (DA) neurons under normal ageing- and Parkinson’s...

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PMID: 33966044
DOI: 10.1038/s41419-021-03742-4

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