Conditional Expression of Parkinson's Disease-Related Mutant  -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

Abstract excerpt

α-Synuclein (α-syn) plays a prominent role in the degeneration of midbrain dopaminergic (mDA) neurons in Parkinson's disease (PD). However, only a few studies on α-syn have been performed in the mDA neurons in vivo, which may be attributed to a lack of α-syn transgenic mice that develop PD-like severe degeneration of mDA neurons. To gain mechanistic insights into the α-syn-induced mDA neurodegeneration, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nerve injury and regeneration
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments