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Article

Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells.

Cell biology and toxicology - 1 Aug 2018

Yu Wenbo, Chen Sheng, Cao Liang, Tang Jie, Xiao Wei, Xiao Baoguo

Abstract excerpt

Alpha-synuclein (α-syn) is associated to Parkinson's disease (PD). The aggregated form of α-syn has potential neurotoxicity. Thus, the clearance of α-syn aggregation is a plausible strategy to delay disease progression of PD. In our study, we found that the treatment of Ginkgolide B (GB) and Ginkgolide K (GK) reduced cell death, and enhanced cell proliferation in SH-SY5Y cells, which overexpressed A53T mutant...

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PMID: 29214369
DOI: 10.1007/s10565-017-9419-4

Genes

BDNF
NEDD4
PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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