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Article

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.

Nucleic acids research - 27 Feb 2015

Betancor Gilberto, Álvarez Mar, Marcelli Barbara, Andrés Cristina, Martínez Miguel A, Menéndez-Arias Luis

Abstract excerpt

HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence of nevirapine. The effect of NNRTIs on the RNase H-mediated cleavage of PPT-containing template-primers has been...

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Identifiers

PMID: 25662223
DOI: 10.1093/nar/gkv077
PMCID: PMC4344514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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