Article
Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant.
Cellular and molecular biology (Noisy-le-Grand, France) - 22 Dec 2012
Michailidis E, Singh K, Ryan E M, Hachiya A, Ong Y T, Kirby K A, Marchand B, Kodama E N, Mitsuya H, Parniak M A, Sarafianos S G
Abstract excerpt
4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) is a highly potent inhibitor of HIV-1 reverse transcriptase (RT). We have previously shown that its exceptional antiviral activity stems from a unique mechanism of action that is based primarily on blocking translocation of RT; therefore we named EFdA a Translocation Defective RT Inhibitor (TDRTI). The N348I mutation at the connection subdomain (CS) of HIV-1 RT confers...
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