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Article

The “Connection” Between HIV Drug Resistance and RNase H

21 Jul 2010

Abstract excerpt

Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the polymerase (pol) domain of reverse transcriptase (RT), most genotypic analysis for drug resistance is limited to the first ~300 amino acids of RT. However,...

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PMID: 21088701
DOI: 10.3390/v2071476

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