Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase.

doi:10.1186/1742-4690-8-69

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase.

Retrovirology - 22 Aug 2011

Radzio Jessica, Sluis-Cremer Nicolas

Abstract excerpt

BACKGROUND: N348I in HIV-1 reverse transcriptase (RT) confers resistance to zidovudine (AZT) and nevirapine. Biochemical studies demonstrated that N348I indirectly increases AZT resistance by decreasing the frequency of secondary ribonuclease H (RNase H) cleavages that reduce the RNA/DNA duplex length of the template/primer (T/P) and diminish the efficiency of AZT-monophosphate (MP) excision. By contrast, there...

Topics

Amino Acid Motifs
Cell Line
DNA Mutational Analysis
HIV Reverse Transcriptase
HIV-1
Humans
Mutation
Nevirapine
Protein Binding
Protein Subunits
Reverse Transcriptase Inhibitors
Ribonuclease H

Source

Open in PubMed Open full text

Identifiers

PMID: 21859446
DOI: 10.1186/1742-4690-8-69
PMCID: PMC3168420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics