Article
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.
The Journal of biological chemistry - 8 Aug 2008
Ehteshami Maryam, Beilhartz Greg L, Scarth Brian J, Tchesnokov Egor P, McCormick Suzanne, Wynhoven Brian, Harrigan P Richard, Götte Matthias
Abstract excerpt
Thymidine analogue-associated mutations (TAMs) in reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) cause resistance to 3'-azido-3'-deoxythymidine (AZT) through excision of the incorporated monophosphate. Mutations in the connection domain of HIV-1 RT can augment AZT resistance. It has been suggested that these mutations compromise RNase H cleavage, providing more time for AZT excision...
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