Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.

Antiviral therapy - 1 Jan 2009

Waters Joshua M, O'Neal Wesley, White Kirsten L, Wakeford Charles, Lansdon Eric B, Harris Jeanette, Svarovskaia Evguenia S, Miller Michael D, Borroto-Esoda Katyna

Abstract excerpt

BACKGROUND: Antiretroviral therapy that targets HIV type-1 (HIV-1) reverse transcriptase (RT) can be linked to mutations in the thumb-connection (amino acids [AA] 241-426) and RNase H (AA 427-560) domains, which could affect drug resistance. METHODS: Genotypical and statistical analyses were performed on HIV-1 RT from 100 antiretroviral treatment-naive and 248 antiretroviral treatment-experienced patients, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkynes
Share to Benzoxazines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclopropanes

Share to Drug Resistance, Multiple, Viral

Share to Lamivudine

Share to Organophosphonates

Share to Stavudine

Share to Tenofovir

Source

Identifiers

PMID: 19430098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.PMID 19430098Read ↗

The “Connection” Between HIV Drug Resistance and RNase HSemantic proximity Read ↗

Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.Semantic proximity Read ↗

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase.Semantic proximity Read ↗

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.Semantic proximity Read ↗

Variability and Signatures of RNase-H Amino Acid Domain and Central Polypurine Tract of HIV-1 B-Subtype from Drug-Naive Individuals.Semantic proximity Read ↗

Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patientsSemantic proximity Read ↗

HIV-1 Reverse Transcriptase: A Therapeutical Target in the SpotlightSemantic proximity Read ↗

HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitorsSemantic proximity Read ↗

Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment.Semantic proximity Read ↗

Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility.Semantic proximity Read ↗

Mutations in Human Immunodeficiency Virus Type 1 RNase H Primer Grip Enhance 3′-Azido-3′-Deoxythymidine ResistanceSemantic proximity Read ↗

Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy FailureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.