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Article

Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levels.

Molecular cell - 5 Mar 2015

Joshi Neeraj, Brown M Scott, Bishop Douglas K, Börner G Valentin

Abstract excerpt

During meiosis, Spo11-induced double-strand breaks (DSBs) are processed into crossovers, ensuring segregation of homologous chromosomes (homologs). Meiotic DSB processing entails 5' end resection and preferred strand exchange with the homolog rather than the sister chromatid (homolog bias). In many organisms, DSBs appear gradually along the genome. Here we report unexpected effects of global DSB levels on local...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25661491
DOI: 10.1016/j.molcel.2014.12.027
PMCID: PMC4392720

Genes

ATM
ATR
TRIP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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