Article
Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast.
PloS one - 1 Jan 2013
Argunhan Bilge, Farmer Sarah, Leung Wing-Kit, Terentyev Yaroslav, Humphryes Neil, Tsubouchi Tomomi, Toyoizumi Hiroshi, Tsubouchi Hideo
Abstract excerpt
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs). The timing of DSB formation is strictly controlled because unscheduled DSB formation is detrimental to genome integrity. Here, we investigated the role of DNA damage...
Topics
- Cell Cycle Proteins
- Chromosomes, Fungal
- DNA Breaks, Double-Stranded
- DNA, Fungal
- DNA-Binding Proteins
- Intracellular Signaling Peptides and Proteins
- Meiosis
- Mutation
- Protein Serine-Threonine Kinases
- Rad51 Recombinase
- Recombination, Genetic
- Saccharomyces cerevisiae