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Article

Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast.

PloS one - 1 Jan 2013

Argunhan Bilge, Farmer Sarah, Leung Wing-Kit, Terentyev Yaroslav, Humphryes Neil, Tsubouchi Tomomi, Toyoizumi Hiroshi, Tsubouchi Hideo

Abstract excerpt

Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs). The timing of DSB formation is strictly controlled because unscheduled DSB formation is detrimental to genome integrity. Here, we investigated the role of DNA damage...

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Source

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Identifiers

PMID: 23762445
DOI: 10.1371/journal.pone.0065875
PMCID: PMC3677890

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast.PMID 23762445Read ↗

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).Semantic proximity Read ↗

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Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast.Semantic proximity Read ↗

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