Article
Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.
PLoS biology - 1 Mar 2016
Jagut Marlène, Hamminger Patricia, Woglar Alexander, Millonigg Sophia, Paulin Luis, Mikl Martin, Dello Stritto Maria Rosaria, Tang Lois, Habacher Cornelia, Tam Angela, Gallach Miguel, von Haeseler Arndt, Villeneuve Anne M, Jantsch Verena
Abstract excerpt
During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are induced than COs, mechanisms are required to establish a regulated number of COs and to repair remaining intermediates as non-crossovers (NCOs). We show that the...
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