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Article

Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1.

Genome research - 1 Feb 2017

Mohibullah Neeman, Keeney Scott

Abstract excerpt

The Spo11-generated double-strand breaks (DSBs) that initiate meiotic recombination are dangerous lesions that can disrupt genome integrity, so meiotic cells regulate their number, timing, and distribution. Mechanisms of this regulation remain poorly understood. Here, we use Spo11-oligonucleotide complexes, a byproduct of DSB formation, to reveal aspects of the contribution of the Saccharomyces cerevisiae DNA...

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Identifiers

PMID: 27923845
DOI: 10.1101/gr.213587.116
PMCID: PMC5287233

Genes

ATM

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Source receipt: pubmed, retrieved 7 Sept 2026.

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