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Article

Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.

Molecular cell - 5 Mar 2015

Vleugel Mathijs, Omerzu Manja, Groenewold Vincent, Hadders Michael A, Lens Susanne M A, Kops Geert J P L

Abstract excerpt

Regulated recruitment of the kinase-adaptor complex BUB1/BUB3 to kinetochores is crucial for correcting faulty chromosome-spindle attachments and for spindle assembly checkpoint (SAC) signaling. BUB1/BUB3 localizes to kinetochores by binding phosphorylated MELT motifs (MELpT) in the kinetochore scaffold KNL1. Human KNL1 has 19 repeats that contain a MELT-like sequence. The repeats are, however, larger than MELT,...

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Source

Identifiers

PMID: 25661489
DOI: 10.1016/j.molcel.2014.12.036

Genes

BUB3
KNL1
BUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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