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Article

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.

Molecular cell - 14 May 2010

Welburn Julie P I, Vleugel Mathijs, Liu Dan, Yates John R, Lampson Michael A, Fukagawa Tatsuo, Cheeseman Iain M

Abstract excerpt

Accurate chromosome segregation requires carefully regulated interactions between kinetochores and microtubules, but how plasticity is achieved to correct diverse attachment defects remains unclear. Here we demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinetochore KNL1/Mis12 complex/Ndc80 complex (KMN) network, the key player in kinetochore-microtubule...

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Source

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Identifiers

PMID: 20471944
DOI: 10.1016/j.molcel.2010.02.034
PMCID: PMC2873218

Genes

KNL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.PMID 20471944Read ↗

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

Structure of the human outer kinetochore KMN network complexSemantic proximity Read ↗

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.Semantic proximity Read ↗

Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.Semantic proximity Read ↗

Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.Semantic proximity Read ↗

Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction.Semantic proximity Read ↗

GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.Semantic proximity Read ↗

Coordination of NDC80 and Ska complexes at the kinetochore-microtubule interface in human cellsSemantic proximity Read ↗

Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.Semantic proximity Read ↗

Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.Semantic proximity Read ↗

Aurora B regulates MCAK at the mitotic centromere.Semantic proximity Read ↗

The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.Semantic proximity Read ↗

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