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Article

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Cell - 3 Oct 2003

Elia Andrew E H, Rellos Peter, Haire Lesley F, Chao Jerry W, Ivins Frank J, Hoepker Katja, Mohammad Duaa, Cantley Lewis C, Smerdon Stephen J, Yaffe Michael B

Abstract excerpt

Polo-like kinases (Plks) perform crucial functions in cell-cycle progression and multiple stages of mitosis. Plks are characterized by a C-terminal noncatalytic region containing two tandem Polo boxes, termed the Polo-box domain (PBD), which has recently been implicated in phosphodependent substrate targeting. We show that the PBDs of human, Xenopus, and yeast Plks all recognize similar...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14532005
DOI: 10.1016/s0092-8674(03)00725-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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