Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational analysis of ammonia transfer along two intramolecular tunnels in Staphylococcus aureus glutamine-dependent amidotransferase (GatCAB).

The journal of physical chemistry. B - 5 Mar 2015

Dewage Sajeewa Walimuni, Cisneros G Andrés

Abstract excerpt

Most bacteria and all archaea misacylate the tRNAs corresponding to Asn and Gln with Asp and Glu (Asp-tRNA(Asn) and Glu-tRNA(Gln)).The GatCAB enzyme of most bacteria converts misacylated Glu-tRNA(Gln) to Gln-tRNA(Gln) in order to enable the incorporation of glutamine during protein synthesis. The conversion process involves the intramolecular transfer of ammonia between two spatially separated active sites. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ammonia
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutamine

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Staphylococcus aureus

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 25654336
DOI: 10.1021/jp5123568
PMCID: PMC5639903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational analysis of ammonia transfer along two intramolecular tunnels in Staphylococcus aureus glutamine-dependent amidotransferase (GatCAB).PMID 25654336Read ↗

Ammonia channel couples glutaminase with transamidase reactions in GatCAB.Semantic proximity Read ↗

Structural basis of RNA-dependent recruitment of glutamine to the genetic code.Semantic proximity Read ↗

Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.Semantic proximity Read ↗

Mutations in Bacillus subtilis glutamine synthetase that block its interaction with transcription factor TnrA.Semantic proximity Read ↗

Ammonium transport proteins with changes in one of the conserved pore histidines have different performance in ammonia and methylamine conduction.Semantic proximity Read ↗

Functional role of Asp160 and the deprotonation mechanism of ammonium in the Escherichia coli ammonia channel protein AmtB.Semantic proximity Read ↗

Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase.Semantic proximity Read ↗

Structural elements in IGP synthase exclude water to optimize ammonia transfer.Semantic proximity Read ↗

Functional connectivity between tRNA binding domains in glutaminyl-tRNA synthetase.Semantic proximity Read ↗

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain.Semantic proximity Read ↗

Redesign of LAOBP to bind novel l-amino acid ligands.Semantic proximity Read ↗

Substrate-Assisted and Enzymatic Pretransfer Editing of Nonstandard Amino Acids by Methionyl-tRNA Synthetase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.