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Article

Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase.

Biochemistry - 13 Sept 2005

Myers Rebecca S, Amaro Rommie E, Luthey-Schulten Zaida A, Davisson V Jo

Abstract excerpt

Imidazole glycerol phosphate (IGP) synthase, a triad glutamine amidotransferase, catalyzes the fifth step in the histidine biosynthetic pathway, where ammonia from glutamine is incorporated into N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (PRFAR) to yield IGP and 5'-(5-aminoimidazole-4-carboxamide) ribonucleotide (AICAR). The triad family of glutamine amidotransferases is...

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Identifiers

PMID: 16142895
DOI: 10.1021/bi050706b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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