Article
Mutations in Bacillus subtilis glutamine synthetase that block its interaction with transcription factor TnrA.
Molecular microbiology - 1 Aug 2002
Fisher Susan H, Brandenburg Jaclyn L, Wray Lewis V
Abstract excerpt
In Bacillus subtilis, the activity of the nitrogen regulatory factor TnrA is regulated through a protein- protein interaction with glutamine synthetase. During growth with excess nitrogen, the feedback-inhibited form of glutamine synthetase binds to TnrA and blocks DNA binding by TnrA. Missense mutations in glutamine synthetase that constitutively express the TnrA-regulated amtB gene were characterized. Four...
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