Article
Redesign of LAOBP to bind novel l-amino acid ligands.
Protein science : a publication of the Protein Society - 1 May 2018
Banda-Vázquez Jesús, Shanmugaratnam Sooruban, Rodríguez-Sotres Rogelio, Torres-Larios Alfredo, Höcker Birte, Sosa-Peinado Alejandro
Abstract excerpt
Computational protein design is still a challenge for advancing structure-function relationships. While recent advances in this field are promising, more information for genuine predictions is needed. Here, we discuss different approaches applied to install novel glutamine (Gln) binding into the Lysine/Arginine/Ornithine binding protein (LAOBP) from Salmonella typhimurium. We studied the ligand binding behavior...
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