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Article

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005

Nakanishi Kotaro, Fukai Shuya, Ikeuchi Yoshiho, Soma Akiko, Sekine Yasuhiko, Suzuki Tsutomu, Nureki Osamu

Abstract excerpt

Lysidine, a lysine-combined modified cytidine, is exclusively located at the anticodon wobble position (position 34) of eubacterial tRNA(Ile)(2) and not only converts the codon specificity from AUG to AUA, but also converts the aminoacylation specificity from recognition by methionyl-tRNA synthetase to that by isoleucyl-tRNA synthetase (IleRS). Here, we report the crystal structure of lysidine synthetase (TilS)...

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Identifiers

PMID: 15894617
DOI: 10.1073/pnas.0501003102
PMCID: PMC1140429

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Source receipt: pubmed, retrieved 7 Sept 2026.

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