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Article

Structural basis of RNA-dependent recruitment of glutamine to the genetic code.

Science (New York, N.Y.) - 30 Jun 2006

Oshikane Hiroyuki, Sheppard Kelly, Fukai Shuya, Nakamura Yuko, Ishitani Ryuichiro, Numata Tomoyuki, Sherrer R Lynn, Feng Liang, Schmitt Emmanuelle, Panvert Michel, Blanquet Sylvain, Mechulam Yves, Söll Dieter, Nureki Osamu

Abstract excerpt

Glutaminyl-transfer RNA (Gln-tRNA(Gln)) in archaea is synthesized in a pretranslational amidation of misacylated Glu-tRNA(Gln) by the heterodimeric Glu-tRNA(Gln) amidotransferase GatDE. Here we report the crystal structure of the Methanothermobacter thermautotrophicus GatDE complexed to tRNA(Gln) at 3.15 angstroms resolution. Biochemical analysis of GatDE and of tRNA(Gln) mutants characterized the catalytic...

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PMID: 16809540
DOI: 10.1126/science.1128470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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