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Article

Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.

Scientific reports - 5 Feb 2015

Zhu Jinhong, Wang Mengyun, Zhu Meiling, He Jin, Wang Jiu-Cun, Jin Li, Wang Xiao-Feng, Xiang Jia-Qing, Wei Qingyi

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1 and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) patients and 1117 cancer-free controls to assess their associations with ESCC risk. We observed no association with ESCC risk for any of the selected SNPs. However, the combined analysis of...

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Share to Carcinoma, Squamous Cell
Share to Class Ia Phosphatidylinositol 3-Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

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Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25654238
DOI: 10.1038/srep08250
PMCID: PMC4318264

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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