Article
Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.
PloS one - 1 Jan 2013
Li Qiaoxin, Gu Chengyuan, Zhu Yao, Wang Mengyun, Yang Yajun, Wang Jiucun, Jin Li, Zhu Mei-Ling, Shi Ting-Yan, He Jing, Zhou Xiaoyan, Ye Ding-wei, Wei Qingyi
Abstract excerpt
BACKGROUND: The mTOR gene regulates cell growth by controlling mRNA translation, ribosome biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was associated with carcinogenesis, and its functional single nucleotide polymorphisms (SNPs) may regulate the expression of mTOR and thus contribute to cancer risk. METHODOLOGY/PRINCIPAL FINDINGS: In a hospital-based case-control study of 1004...
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