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Article

Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.

Journal of cellular and molecular medicine - 1 Apr 2016

Zhu Jinhong, Wang Mengyun, He Jing, Zhu Meiling, Wang Jiu-Cun, Jin Li, Wang Xiao-Feng, Yang Ya-Jun, Xiang Jia-Qing, Wei Qingyi

Abstract excerpt

Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma (ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers, including ESCC. Some single nucleotide polymorphisms (SNPs) in genes involved in this pathway may contribute to ESCC susceptibility. We selected five potentially functional SNPs in AKT1 (rs2494750, rs2494752 and rs10138277) and AKT2 (rs7254617...

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Share to Carcinoma, Squamous Cell
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Share to Multifactor Dimensionality Reduction
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Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 26828791
DOI: 10.1111/jcmm.12750
PMCID: PMC5126231

Genes

AKT1
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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