Article
A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population.
Journal of bone and mineral metabolism - 1 Nov 2015
Zhou Heying, Mori Seijiro, Tanaka Masashi, Sawabe Motoji, Arai Tomio, Muramatsu Masaaki, Mieno Makiko Naka, Shinkai Shoji, Yamada Yoshiji, Miyachi Motohiko, Murakami Haruka, Sanada Kiyoshi, Ito Hideki
Abstract excerpt
Werner syndrome is a rare autosomal recessive disorder caused by mutations in the human WRN gene and characterized by the early onset of normal aging symptoms. Given that patients with this disease exhibit osteoporosis, the present study aimed to determine whether the WRN gene contributes to the etiology of osteoporosis. A genetic association study of eight non-synonymous polymorphisms in the WRN gene and the...
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