Article
Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women.
Geriatrics & gerontology international - 1 Sept 2009
Ohnaka Keizo, Yamamoto Ken, Nakamura Kenjiro, Adachi Masahiro, Kawate Hisaya, Kono Suminori, Takayanagi Ryoichi
Abstract excerpt
AIM: Recent studies have demonstrated that the Wnt signaling pathway plays an important role in bone metabolism. The purpose of this study was to examine whether the gene of secreted frizzled-related protein 1 (SFRP1), a Wnt antagonist, is involved in the etiology of osteoporosis using association study. METHODS: Seven single nucleotide polymorphisms (SNP) in the SFRP1 gene were genotyped and analyzed for...
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