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Article

Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan.

Cancer science - 1 Feb 2008

Nakayama Robert, Sato Yasunori, Masutani Mitsuko, Ogino Hideki, Nakatani Fumihiko, Chuman Hirokazu, Beppu Yasuo, Morioka Hideo, Yabe Hiroo, Hirose Hiroshi, Sugimura Haruhiko, Sakamoto Hiromi, Ohta Tsutomu, Toyama Yoshiaki, Yoshida Teruhiko, Kawai Akira

Abstract excerpt

Bone and soft tissue sarcomas (BSTSs) are rare malignant tumors of mesenchymal origin. Although BSTSs frequently occur in some hereditary cancer syndromes with germline mutations of DNA repair genes, genetic factors responsible for sporadic cases have not been determined. In the present study we...

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Identifiers

PMID: 18271933
DOI: 10.1111/j.1349-7006.2007.00692.x
PMCID: PMC11159914

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18271933-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan.PMID 18271933Read ↗

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NF1 and PTEN gene polymorphisms and the susceptibility to soft tissue sarcomas in a Chinese population: A case-control study.Semantic proximity Read ↗

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Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.Semantic proximity Read ↗

Case Report: A novel WRN mutation in Werner syndrome patient with diabetic foot disease and myelodysplastic syndrome.Semantic proximity Read ↗

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