Article
Implementation of personalized medicine for fracture risk assessment in osteoporosis.
Geriatrics & gerontology international - 1 Mar 2016
Mori Seijiro, Zhou Heying
Abstract excerpt
The present review summarizes our efforts to identify genetic polymorphisms associated with osteoporotic fractures and to establish a genetic risk score (GRS) to predict fracture risk in consecutive Japanese autopsy cases carried out at Tokyo Metropolitan Geriatric Hospital between 1995 and 2011. Three single nucleotide polymorphisms in transforming growth factor β-1, rs1800470; thrombospondin, type 1,...
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