Article
An osteoprotegerin gene polymorphism is associated with an increased risk of hip fracture in Japanese patients with rheumatoid arthritis: results from the IORRA Observational Cohort Study.
PloS one - 1 Jan 2014
Yoshida Shinji, Ikari Katsunori, Furuya Takefumi, Toyama Yoshiaki, Taniguchi Atsuo, Yamanaka Hisashi, Momohara Shigeki
Abstract excerpt
INTRODUCTION: Patients with rheumatoid arthritis (RA) have a higher prevalence of osteoporosis and hip fracture than healthy individuals. Multiple genetic loci for osteoporotic fracture were identified in recent genome-wide association studies. The purpose of this study was to identify genetic variants associated with the occurrence of hip fracture in Japanese patients with RA. METHODS: DNA samples from 2,282...
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